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. 2016 Apr:76:211-2.
doi: 10.1016/j.yrtph.2016.01.001. Epub 2016 Jan 11.

Opinion of the Scientific Committee on Consumer safety (SCCS) - Opinion on the safety of the use of Methylisothiazolinone (MI) (P94), in cosmetic products (sensitisation only)

Scientific Committee Of Consumer Safety  1 ; A M Giménez-Arnau  2
Affiliations

Opinion of the Scientific Committee on Consumer safety (SCCS) - Opinion on the safety of the use of Methylisothiazolinone (MI) (P94), in cosmetic products (sensitisation only)

Scientific Committee Of Consumer Safety et al. Regul Toxicol Pharmacol. 2016 Apr.

Abstract

The information provided does not support the safe use of MI as a preservative in rinse-off cosmetic products up to a concentration limit of 100 ppm from the view of induction of contact allergy. For rinse-off cosmetic products, a concentration of 15 ppm (0.0015%) MI is considered safe for the consumer from the point of view of induction of contact allergy. The information provided does not support the safe use of MI as a preservative in leave-on hair cosmetic products up to a concentration limit of 100 ppm from the point of view of induction of contact allergy. The concerns and opinions raised in SCCS Opinion SCCS/1521/13 (12 December 2013 with revision 27 March 2014) remain. The results of the recent Scandinavian study do not support safety of MI in rinse-off products at either 100 ppm or at 50 ppm for elicitation or induction.

Keywords: CAS 2682-20-4; EC 220-239-6; Methylisothiazolinone (MI) (P94); Regulation 1223/2009; SCCS; Scientific opinion; Sensitisation.

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