Pulegone

Safety Summary

Regulatory Status

Sources

No citations are recorded specifically for the human adult context, so the record-wide source list is shown. It backs the record, not this particular band.

• PubChem Compound Database DATABASE · 2026
• FDA Adverse Event Reporting System — Pennyroyal Oil + Pulegone Hepatotoxicity Case-Fatality Framework (Anderson et al. 1996 case-series; abortifacient-misuse fatality cluster) REGULATORY · 1996
• IFRA Standard 51st Amendment — Pulegone in fragrance products (skin-allergen + reproductive-toxicity + hepatotoxicity restriction; usage-level limits per product category) REGULATORY · 2024
• EFSA Scientific Opinion on Pulegone and Menthofuran in Flavourings (FGE.92 + FGE.92.Rev.1 — restriction of pulegone-bearing herbal products in foodstuffs; herbal-tea cohort analysis) REGULATORY · 2016
• EU Cosmetics Regulation 1223/2009 Annex III — Pulegone restriction (toothpaste + leave-on/rinse-off product limits per concentration framework) REGULATORY · 2009
• Anderson IB, Mullen WH, Meeker JE et al. — Pennyroyal toxicity: measurement of toxic metabolite levels in two cases and review of the literature (canonical pennyroyal-oil/pulegone-fatality cohort, JAMA Internal Medicine) STUDY · 1996
• IARC Monographs, List of Classifications REGULATORY · 2026
• PubChem computed properties for CID 442495 (computed, not measured; as recorded by PubChem) DATABASE · 2026
• OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26) REGULATORY
• TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018) REFERENCE_DATABASE
• where to look Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 442495; where-to-look, not a source of this value) DATABASE · 2026
• EPA CompTox CTX API: predicted properties for DTXSID2025975 (Pulegone) REFERENCE
• PubChem computed structure descriptors for CID 442495 (computed, not measured; as recorded by PubChem) DATABASE · 2026

Same data as the API response, which is open and needs no key. The full per-record source list is available to authenticated callers.