Vanillin (vanilla flavor; synthetic vanilla)

Safety Summary

Regulatory Status

Sources

No citations are recorded specifically for the human adult context, so the record-wide source list is shown. It backs the record, not this particular band.

• Vanillin CAS 121-33-5 4-Hydroxy-3-Methoxybenzaldehyde C8H8O3 FL04.010 FEMA 3107 No E-Number [NOTE: registry E466 entry incorrect — E466 is CMC/carboxymethylcellulose]; FDA GRAS 21 CFR 182.60 Synthetic Flavoring; JECFA ADI 10 mg/kg/day 1967 Confirmed; EFSA 2012 EFSA Journal 10(7):2817 No Safety Concern EDI 0.4-1.2 mg/person/day; Vanilla planifolia Bourbon Madagascar 1.5-3% Dry Bean; Synthetic 99%+ Market Guaiacol Glyoxylic Acid Process ~85% Production Lignin Borregaard Norway Eugenol Clove; Natural Label Biosynthetic Ferulic Acid Rice Bran Aspergillus Niger E. Coli; Labeling: Vanilla Extract 21 CFR 169 vs Artificial Flavor vs Natural Vanilla Flavor Biosynthetic; Vanillic Acid Homovanillic Acid Phenolic Metabolites Normal Diet; Anti-Sickling HbS Polymerization Research Zaugg 1977 Bookchin Not Food Safety; ~20000 Tonnes/Year Commercial Production; Madagascar Crop Cycle Price Volatility $100-600/kg Natural vs $15-25/kg Synthetic REGULATORY · 2012
• § 169.175 Vanilla extract. REGULATORY
• identity database ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances) REGULATORY · 2026
• where to look PubChem: Toxicity section (CID 1183) PUBCHEM
• Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE) REGULATORY
• CompTox Chemicals Dashboard: Release Notes (EPA) REGULATORY
• PubChem computed properties for CID 1183 (computed, not measured; as recorded by PubChem) DATABASE · 2026
• Consolidated TEXT: 32009R1223 — EN — 18.05.2026 (Regulation (EC) No 1223/2009, cosmetic products) REGULATORY
• OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26) REGULATORY
• Permissible Exposure Limits – OSHA Annotated Table Z-1 REGULATORY
• where to look CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 1183; where-to-look, not a source of this value) DATABASE · 2026
• where to look Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 1183; where-to-look, not a source of this value) DATABASE · 2026
• EPA CompTox CTX API: predicted properties for DTXSID0021969 (Vanillin (vanilla flavor; synthetic vanilla)) REFERENCE
• PubChem computed structure descriptors for CID 1183 (computed, not measured; as recorded by PubChem) DATABASE · 2026

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