Propionic acid (E280)

Safety Summary

Regulatory Status

Sources

No citations are recorded specifically for the human adult context, so the record-wide source list is shown. It backs the record, not this particular band.

• Propionic Acid E280 CAS 79-09-4 CH3CH2COOH pKa 4.87 E280-E283; EFSA 2014; FDA GRAS 21 CFR 184.1081; Swiss Cheese 1-2% Propionibacterium Freudenreichii Shermanii Lactate Fermentation; Gut Microbiota Bacteroides Veillonella SCFA Portal Vein 3-4 µM; Succinyl-CoA TCA Propionyl-CoA Methylmalonyl-CoA Pathway; Propionic Acidemia PA Methylmalonic Acidemia MMA Rare Inborn Error Metabolic Acidosis; Grain Preservation High-Moisture Animal Feed; Propanoate Ester Fruit Flavors; Herbicide Fenoprop Intermediate; Autism ICV Injection Controversy Physiologically Irrelevant REGULATORY · 2014
• Scientific Opinion on the re-evaluation of propionic acid (E 280), sodium propionate (E 281), calcium propionate (E 282) and potassium propionate (E 283) as food additives REGULATORY
• identity database ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances) REGULATORY · 2026
• where to look PubChem: Toxicity section (CID 1032) PUBCHEM
• Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE) REGULATORY
• CompTox Chemicals Dashboard: Release Notes (EPA) REGULATORY
• NIOSH Pocket Guide to Chemical Hazards - Propionic acid REGULATORY
• Consolidated TEXT: 32000L0039 — EN — 20.05.2021 REGULATORY
• PubChem computed properties for CID 1032 (computed, not measured; as recorded by PubChem) DATABASE · 2026
• where to look EPA ECOTOX Knowledgebase ASCII release ecotox_ascii_09_15_2026 DATABASE
• OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26) REGULATORY
• where to look CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 1032; where-to-look, not a source of this value) DATABASE · 2026
• where to look Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 1032; where-to-look, not a source of this value) DATABASE · 2026
• where to look The National Institute for Occupational Safety and Health (NIOSH), as recorded by PubChem (Experimental Properties, CID 1032; where-to-look, not a source of this value) DATABASE · 2026
• where to look PAC Chemical Database, U.S. Department of Energy, as recorded by PubChem (Experimental Properties, CID 1032; where-to-look, not a source of this value) DATABASE · 2026
• EPA CompTox CTX API: predicted properties for DTXSID8025961 (Propionic acid (E280)) REFERENCE
• ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP) REGULATORY
• PubChem computed structure descriptors for CID 1032 (computed, not measured; as recorded by PubChem) DATABASE · 2026
• Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006: Annex VI, Part 3, Table 3.1 (Official Journal L 353, 31.12.2008) REGULATORY · 2008

Same data as the API response, which is open and needs no key. The full per-record source list is available to authenticated callers.