Carboxymethylcellulose (CMC; Sodium CMC; E466)

Safety Summary

Regulatory Status

Sources

No citations are recorded specifically for the human adult context, so the record-wide source list is shown. It backs the record, not this particular band.

• Carboxymethylcellulose CMC E466 CAS 9004-32-4 Sodium CMC Cellulose Gum DS 0.6-0.95 MW 50k-700k Da; EFSA 2023 ADI Withdrawn Insufficient Data No NOAEL Gut Microbiota; Chassaing 2015 Nature doi:10.1038/nature14232 C57BL/6 Mice 1% Drinking Water 750mg/kg Gut Microbiota Altered Proteobacteria Mucus Penetration Low-Grade Colitis; IL-10-/- Mice Severe Colitis; Germ-Free Mice No Effect Microbiota-Dependent; Chassaing 2022 Cell Host Microbe doi:10.1016/j.chom.2021.12.001 Human Feeding Study n=16 Crossover E. coli Flagellated Proteobacteria; TLR5 TLR4 NF-kB Inflammatory Cascade Mucin Displacement; Ice Cream Ice Crystal Control Cream Cheese Dressings Beverages; Pharmaceutical Tablet Binder Disintegrant Laxative 1.5-6g/day; Prior ADI 0-25 mg/kg/day Withdrawn; FDA GRAS Not Re-Evaluated REGULATORY · 2023
• where to look PubChem: Toxicity section (CID 6328154) PUBCHEM
• Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE) REGULATORY
• CompTox Chemicals Dashboard: Release Notes (EPA) REGULATORY
• OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26) REGULATORY
• Permissible Exposure Limits – OSHA Annotated Table Z-1 REGULATORY
• PubChem computed properties for CID 6328154 (computed, not measured; as recorded by PubChem) DATABASE · 2026
• PubChem computed structure descriptors for CID 6328154 (computed, not measured; as recorded by PubChem) DATABASE · 2026

Same data as the API response, which is open and needs no key. The full per-record source list is available to authenticated callers.