Isophorone

Safety Summary

Regulatory Status

Sources

No citations are recorded specifically for the human adult context, so the record-wide source list is shown. It backs the record, not this particular band.

• US EPA IRIS 1989 Isophorone Group C Possible Human Carcinogen RfD 0.2 mg/kg/day; CERCLA Hazardous Substance; Hepatotoxic Nephrotoxic High Doses Rodents; α,β-Unsaturated Ketone Skin Sensitizer; OSHA PEL 25 ppm; IPDI Polyurethane Precursor Solvent REGULATORY · 1989
• § 1910.1000 Air contaminants. REGULATORY
• IARC Monographs, List of Classifications REGULATORY · 2026
• Isophorone | CASRN 78-59-1 | DTXSID8020759 | IRIS | US EPA, ORD REGULATORY
• US EPA, Drinking Water Standards and Health Advisories Tables (2018 Edition) REGULATORY
• 71 FR 45403 (2006-08-09) FR Doc E6-12547: Isophorone; Exemption from the Requirement of a Tolerance REGULATORY
• identity database ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances) REGULATORY · 2026
• where to look PubChem: Toxicity section (CID 6544) PUBCHEM
• Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE) REGULATORY
• CompTox Chemicals Dashboard: Release Notes (EPA) REGULATORY
• Permissible Exposure Limits – OSHA Annotated Table Z-1 REGULATORY
• Toxicological Profile for Isophorone (ATSDR, July 2018) ASSESSMENT
• Isophorone; CASRN 78-59-1: IRIS Chemical Assessment Summary ASSESSMENT
• EPA ToxRefDB 3.0 point-of-departure release (pod.csv) DATABASE
• PubChem computed properties for CID 6544 (computed, not measured; as recorded by PubChem) DATABASE · 2026
• where to look EPA ECOTOX Knowledgebase ASCII release ecotox_ascii_09_15_2026 DATABASE
• OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26) REGULATORY
• where to look CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 6544; where-to-look, not a source of this value) DATABASE · 2026
• where to look Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 6544; where-to-look, not a source of this value) DATABASE · 2026
• EPA CompTox CTX API: predicted properties for DTXSID8020759 (Isophorone) REFERENCE
• ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP) REGULATORY
• PubChem computed structure descriptors for CID 6544 (computed, not measured; as recorded by PubChem) DATABASE · 2026
• Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006: Annex VI, Part 3, Table 3.1 (Official Journal L 353, 31.12.2008) REGULATORY · 2008

Same data as the API response, which is open and needs no key. The full per-record source list is available to authenticated callers.