Simvastatin

Safety Summary

Regulatory Status

Sources

These citations are the ones recorded for the human adult context.

• FDA Prescribing Information: Simvastatin (Zocor) — CYP3A4 substrate; 80mg restriction 2011; extensive interaction list; amiodarone/verapamil caps; gemfibrozil contraindication; pediatric HeFH; 4S trial; grapefruit; red yeast rice; evening dosing (2023) REGULATORY · 2023
• ASPCA Animal Poison Control Center: Cardiac Drug Toxicosis in Pets — statin myopathy in cats; beta-blocker bradycardia dogs; CCB toxicity (amlodipine/diltiazem); ACE inhibitor renal effects; warfarin anticoagulant; furosemide; toxic dose thresholds (2023) VETERINARY · 2023
• OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26) REGULATORY
• Permissible Exposure Limits – OSHA Annotated Table Z-1 REGULATORY
• EPA CompTox CTX API: predicted properties for DTXSID0023581 (Simvastatin) REFERENCE

Same data as the API response, which is open and needs no key. The full per-record source list is available to authenticated callers.