Trimethoprim

Safety Summary

Regulatory Status

Sources

These citations are the ones recorded for the human adult context.

• FDA Prescribing Information: Trimethoprim (Primsol/Proloprim) — DHFR inhibitor; UTI monotherapy; TMP-SMX combination; hyperkalemia with ACE/ARB; pseudo-creatinine elevation; folate antagonist; neonatal kernicterus; PCP prophylaxis; G6PD; leucovorin antidote (2023) REGULATORY · 2023
• WHO AWaRe Classification of Antibiotics — Access/Watch/Reserve categories; stewardship framework; amoxicillin Access category; ciprofloxacin/azithromycin Watch; vancomycin Reserve; resistance drivers; outpatient prescribing guidance (2023) REGULATORY · 2023
• where to look PubChem: Toxicity section (CID 5578) PUBCHEM
• OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26) REGULATORY
• Permissible Exposure Limits – OSHA Annotated Table Z-1 REGULATORY
• EPA CompTox CTX API: predicted properties for DTXSID3023712 (Trimethoprim) REFERENCE

Same data as the API response, which is open and needs no key. The full per-record source list is available to authenticated callers.