Amitriptyline

Safety Summary

Regulatory Status

Sources

These citations are the ones recorded for the human adult context.

• FDA Prescribing Information: Amitriptyline (Elavil) — depression; TCA; QRS widening; sodium bicarbonate antidote; anticholinergic; Beers Criteria avoid ≥65yr; pain/migraine off-label; pediatric enuresis; narrow therapeutic index; CYP2D6 polymorphism (2023) REGULATORY · 2023
• ASPCA Animal Poison Control Center: Tricyclic Antidepressant Toxicosis in Dogs — sodium channel blockade; cardiac arrhythmias; ECG monitoring; sodium bicarbonate treatment; anticholinergic toxidrome; toxic dose thresholds; comparison to SSRI toxicity (2023) VETERINARY · 2023
• identity database ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances) REGULATORY · 2026
• where to look PubChem: Toxicity section (CID 2160) PUBCHEM
• TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018) REFERENCE_DATABASE
• OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26) REGULATORY
• Permissible Exposure Limits – OSHA Annotated Table Z-1 REGULATORY
• where to look DrugBank, as recorded by PubChem (Experimental Properties, CID 2160; where-to-look, not a source of this value) DATABASE · 2026
• EPA CompTox CTX API: predicted properties for DTXSID7022594 (Amitriptyline) REFERENCE

Same data as the API response, which is open and needs no key. The full per-record source list is available to authenticated callers.