Malic acid

Safety Summary

Regulatory Status

Sources

These citations are the ones recorded for the human adult context.

• FDA GRAS: Malic Acid (E296) — TCA cycle intermediate; apple acid 3–5 g/kg; wine acidification; sour candy; supplement fibromyalgia; ADI not specified; dental erosion; malolactic fermentation (2021) REGULATORY · 2021
• EFSA ANS Panel: Re-evaluation of Malic Acid (E 296) — ADI not specified; L vs DL stereochemistry; dietary exposure; sour candy oral injury; dental erosion; TCA cycle metabolism; infant formula safety (2015) REGULATORY · 2015
• identity database ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances) REGULATORY · 2026
• where to look PubChem: Toxicity section (CID 525) PUBCHEM
• OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26) REGULATORY
• Permissible Exposure Limits – OSHA Annotated Table Z-1 REGULATORY
• EPA CompTox CTX API: predicted properties for DTXSID0027640 (Malic acid) REFERENCE

Same data as the API response, which is open and needs no key. The full per-record source list is available to authenticated callers.