Tetrahydrofuran

Safety Summary

Regulatory Status

Sources

These citations are the ones recorded for the human adult context.

• NIOSH Pocket Guide: Tetrahydrofuran — IDLH 2000 ppm; PEL 200 ppm; peroxide formation hazard; CNS depression; reproductive toxicant; pharmaceutical ICH Class 2 solvent; skin notation (2019) REGULATORY · 2019
• OSHA: THF in PVC Pipe Cement — plumbing worker exposure; confined space inhalation; engineering controls; dermal absorption; ACGIH TLV 50 ppm reproductive concern; peroxide explosion risk (2020) REGULATORY · 2020
• § 1910.1000 Air contaminants. REGULATORY
• PROPOSITION 65 LIST OF CARCINOGENS OR REPRODUCTIVE TOXICANTS REGULATORY · 2026
• IARC Monographs, List of Classifications REGULATORY · 2026
• Tetrahydrofuran | CASRN 109-99-9 | DTXSID1021328 | IRIS | US EPA, ORD REGULATORY
• identity database ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances) REGULATORY · 2026
• where to look PubChem: Toxicity section (CID 8028) PUBCHEM
• NIOSH Pocket Guide to Chemical Hazards: Tetrahydrofuran (npgd0602) REGULATORY
• Consolidated TEXT: 32000L0039 — EN — 20.05.2021 REGULATORY
• where to look Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 8028; where-to-look, not a source of this value) DATABASE · 2026
• EPA CompTox CTX API: predicted properties for DTXSID1021328 (Tetrahydrofuran) REFERENCE
• ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP) REGULATORY

Same data as the API response, which is open and needs no key. The full per-record source list is available to authenticated callers.