Urea

Safety Summary

Regulatory Status

Sources

These citations are the ones recorded for the human adult context.

• FDA GRAS: Urea — chewing gum humectant; OTC topical keratolytic/humectant 10–40%; oral LD50 8500 mg/kg; BUN uremia marker; urea cycle product; low acute toxicity (2021) REGULATORY · 2021
• NIOSH: Urea — fertilizer production; agricultural handling; sweat constituent; pediatric dermatological use; UF resin workplace distinction; urea breath test; uremia pathophysiology (2019) REGULATORY · 2019
• Urea | CASRN 57-13-6 | DTXSID4021426 | IRIS | US EPA, ORD REGULATORY
• identity database ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances) REGULATORY · 2026
• where to look PubChem: Toxicity section (CID 1176) PUBCHEM
• OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26) REGULATORY
• where to look CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 1176; where-to-look, not a source of this value) DATABASE · 2026
• EPA CompTox CTX API: predicted properties for DTXSID4021426 (Urea) REFERENCE

Same data as the API response, which is open and needs no key. The full per-record source list is available to authenticated callers.