Citric acid

Safety Summary

Regulatory Status

Sources

These citations are the ones recorded for the human adult context.

• FDA GRAS: Citric Acid (21 CFR 184.1033) — GRAS acidulant; not specified ADI; soft drinks; effervescent tablets; chelation; TCA cycle metabolite; dental erosion concern (2021) REGULATORY · 2021
• EFSA ANS Panel: Re-evaluation of Citric Acid (E 330) — ADI not specified; dietary exposure assessment; dental erosion; calcium chelation; sour candy oral injury; safety conclusion (2018) REGULATORY · 2018
• identity database ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances) REGULATORY · 2026
• where to look PubChem: Toxicity section (CID 311) PUBCHEM
• OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26) REGULATORY
• where to look ILO-WHO International Chemical Safety Cards (ICSCs), as recorded by PubChem (Experimental Properties, CID 311; where-to-look, not a source of this value) DATABASE · 2026
• EPA CompTox CTX API: predicted properties for DTXSID3020332 (Citric acid) REFERENCE
• ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP) REGULATORY

Same data as the API response, which is open and needs no key. The full per-record source list is available to authenticated callers.