Dextromethorphan (DXM)

Safety Summary

Regulatory Status

Sources

These citations are the ones recorded for the human adult context.

• FDA Drug Safety Communication: DXM Cough Suppressants — Not for children <4 years; CYP2D6 poor metabolizer drug interaction; serotonin syndrome risk; adolescent abuse robotripping; Coricidin HBP triple-C abuse; NMDA antagonism high dose (2010) REGULATORY · 2010
• American Association of Poison Control Centers (AAPCC): National Poison Data System Annual Report — Pediatric cocaine/stimulant exposures; body packing emergencies; levamisole agranulocytosis; accidental child ingestion outcomes (2022) REGULATORY · 2022
• where to look PubChem: Toxicity section (CID 5360696) PUBCHEM
• OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26) REGULATORY
• Permissible Exposure Limits – OSHA Annotated Table Z-1 REGULATORY
• EPA CompTox CTX API: predicted properties for DTXSID3022908 (Dextromethorphan (DXM)) REFERENCE

Same data as the API response, which is open and needs no key. The full per-record source list is available to authenticated callers.