Methadone

Safety Summary

Regulatory Status

Sources

These citations are the ones recorded for the human adult context.

• SAMHSA: Opioid Treatment Program (OTP) Regulations — Methadone for OUD Treatment, Take-Home Dose Requirements, QTc Monitoring, Long Half-Life Stacking Risk, and Diversion Prevention Protocols (42 CFR Part 8; 2023) REGULATORY · 2023
• US CDC: Methadone Prescribing — Disproportionate Overdose Mortality, Pediatric Single-Tablet Fatality Reports, Extended 24–48 Hour Monitoring Window, QTc Prolongation (Torsades de Pointes), and CYP3A4/2D6 Drug Interaction Table (2020) REGULATORY · 2020
• identity database ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances) REGULATORY · 2026
• where to look PubChem: Toxicity section (CID 4095) PUBCHEM
• OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26) REGULATORY
• Permissible Exposure Limits – OSHA Annotated Table Z-1 REGULATORY
• EPA CompTox CTX API: predicted properties for DTXSID7023273 (Methadone) REFERENCE

Same data as the API response, which is open and needs no key. The full per-record source list is available to authenticated callers.