Buprenorphine

Safety Summary

Regulatory Status

Sources

These citations are the ones recorded for the human adult context.

• US FDA: Buprenorphine — OUD Treatment Approvals (Suboxone, Sublocade, Probuphine), Ceiling Effect on Respiratory Depression, Naloxone Abuse Deterrent Component, Pediatric Exposure Risk, Feline Analgesic Use, and Pregnancy/NOWS Outcomes (2022) REGULATORY · 2022
• SAMHSA: Clinical Practice Guideline for the Treatment of Opioid Use Disorder — Buprenorphine Prescribing, Precipitated Withdrawal Management, Child Exposure Prevention (Suboxone film child-resistant packaging), and Comparison with Methadone (2023) REGULATORY · 2023
• identity database ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances) REGULATORY · 2026
• OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26) REGULATORY
• Permissible Exposure Limits – OSHA Annotated Table Z-1 REGULATORY
• EPA CompTox CTX API: predicted properties for DTXSID2022705 (Buprenorphine) REFERENCE

Same data as the API response, which is open and needs no key. The full per-record source list is available to authenticated callers.