Tramadol

Safety Summary

Regulatory Status

Sources

These citations are the ones recorded for the human adult context.

• US DEA: Tramadol — Schedule IV Rescheduling (2014), Dual Opioid/Serotonergic Mechanism, Serotonin Syndrome Risk, CYP2D6 Ultra-Rapid Metabolizer Hazard, Seizure Risk, and International Misuse Patterns (2022) REGULATORY · 2022
• US FDA: Tramadol — Pediatric Contraindication Safety Communication (2017, Children <12 and Post-T&A Adolescents), CYP2D6 Ultra-Rapid Metabolizer Deaths, Black Box Warning, and Drug Interaction Profile (Serotonin Syndrome, MAOIs) (2022) REGULATORY · 2022
• identity database ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances) REGULATORY · 2026
• where to look PubChem: Toxicity section (CID 33741) PUBCHEM
• OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26) REGULATORY
• Permissible Exposure Limits – OSHA Annotated Table Z-1 REGULATORY
• where to look DrugBank, as recorded by PubChem (Experimental Properties, CID 33741; where-to-look, not a source of this value) DATABASE · 2026
• EPA CompTox CTX API: predicted properties for DTXSID90858931 (Tramadol) REFERENCE

Same data as the API response, which is open and needs no key. The full per-record source list is available to authenticated callers.