Hydrocodone

Safety Summary

Regulatory Status

Sources

These citations are the ones recorded for the human adult context.

• US DEA: Hydrocodone Combination Products — Rescheduling from Schedule III to Schedule II (2014), Prescribing Volume Reduction Post-Rescheduling, CYP2D6 Ultra-Rapid Metabolizer Risk, and Extended-Release Formulation Hazard (2022) REGULATORY · 2022
• US FDA: Hydrocodone/Acetaminophen Combination Products — ≤325 mg APAP/Tablet Mandate, Extended-Release Hydrocodone (Zohydro ER) Risk Evaluation, Pediatric Accidental Ingestion Data, and Abuse-Deterrent Formulation Requirements (2022) REGULATORY · 2022
• where to look PubChem: Toxicity section (CID 5284569) PUBCHEM
• OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26) REGULATORY
• Permissible Exposure Limits – OSHA Annotated Table Z-1 REGULATORY
• where to look Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 5284569; where-to-look, not a source of this value) DATABASE · 2026
• EPA CompTox CTX API: predicted properties for DTXSID8023131 (Hydrocodone) REFERENCE

Same data as the API response, which is open and needs no key. The full per-record source list is available to authenticated callers.