Cocaine

Safety Summary

Regulatory Status

Sources

These citations are the ones recorded for the human adult context.

• US DEA: Cocaine — Schedule II Controlled Substance Classification, Legitimate Medical Use (Topical ENT Anesthesia), Abuse Potential, and Federal Scheduling History (21 USC 812; 2022) REGULATORY · 2022
• Goldfrank's Toxicologic Emergencies: Cocaine — Mechanism of Action (Dopamine/NE/5HT Reuptake Inhibition), Cardiovascular Toxicity (MI, Vasospasm, Aortic Dissection), CNS Effects, Crack vs. Intranasal Routes, and Beta-Blocker Contraindication (11th Ed., 2019) ACADEMIC · 2019
• OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26) REGULATORY
• where to look Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 446220; where-to-look, not a source of this value) DATABASE · 2026
• EPA CompTox CTX API: predicted properties for DTXSID2038443 (Cocaine) REFERENCE

Same data as the API response, which is open and needs no key. The full per-record source list is available to authenticated callers.