Saccharin

Safety Summary

Regulatory Status

Sources

These citations are the ones recorded for the human adult context.

• US FDA: Saccharin — GRAS Affirmation (2010), History of Proposed Bans, NTP Delisting (2000), ADI 5 mg/kg bw/day, and Current Regulatory Status in US Food Supply (2022) REGULATORY · 2022
• IARC Monographs Supplement 7 (1987): Saccharin — Reclassification to Group 3 (Not Classifiable as to Carcinogenicity to Humans); Male Rat-Specific Alpha-2u-Globulin Bladder Tumor Mechanism; Species Specificity Not Applicable to Humans ACADEMIC · 1987
• US National Toxicology Program: Saccharin Removal from Report on Carcinogens (2000) — Rat Bladder Mechanism Human Non-Relevance, Extensive Human Epidemiology Data, and Prop 65 Delisting (2001) REGULATORY · 2000
• PROPOSITION 65 LIST OF CARCINOGENS OR REPRODUCTIVE TOXICANTS REGULATORY · 2026
• IARC Monographs, List of Classifications REGULATORY · 2026
• identity database ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances) REGULATORY · 2026
• where to look PubChem: Toxicity section (CID 5143) PUBCHEM
• Permissible Exposure Limits – OSHA Annotated Table Z-1 REGULATORY
• where to look Haz-Map, Information on Hazardous Chemicals and Occupational Diseases, as recorded by PubChem (Experimental Properties, CID 5143; where-to-look, not a source of this value) DATABASE · 2026
• where to look Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 5143; where-to-look, not a source of this value) DATABASE · 2026
• EPA CompTox CTX API: predicted properties for DTXSID5021251 (Saccharin) REFERENCE

Same data as the API response, which is open and needs no key. The full per-record source list is available to authenticated callers.