Methotrexate
CAS: 59-05-2 | Type: active_pharmaceutical
Moderate To High Risk (Adults)
Safety Summary
Hazard Profilehazardous
Risk (Adults)Moderate To High
Risk (Dogs)High
Risk (Cats)High
Regulatory Status
SummaryIARC: Group 3 | California Prop 65 listed
Molecular FormulaC20H22N8O5
Molecular Weight454.4
Sources
These citations are the ones recorded for the human adult context.
- IARC Monographs Supplement 7 (1987): Methotrexate — Group 3 (Not classifiable as to its carcinogenicity to humans) REGULATORY · 1987
- US FDA: Methotrexate Prescribing Information — Indications, Dosing, Black Box Warnings (Myelosuppression, Hepatotoxicity, Pulmonary Toxicity, Teratogenicity), and Leucovorin Rescue REGULATORY · 2022
- IARC Monographs, List of Classifications REGULATORY · 2026
- where to look PubChem: Toxicity section (CID 126941) PUBCHEM
- OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26) REGULATORY
- TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018) REFERENCE_DATABASE
- where to look Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 126941; where-to-look, not a source of this value) DATABASE · 2026
- EPA CompTox CTX API: predicted properties for DTXSID4020822 (Methotrexate) REFERENCE
Same data as the API response, which is open and needs no key. The full per-record source list is available to authenticated callers.
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