Pyrrolizidine alkaloids (hepatotoxic class)

Safety Summary

Regulatory Status

Sources

These citations are the ones recorded for the human adult context.

• EFSA Panel on Contaminants in the Food Chain: Pyrrolizidine Alkaloids in Food and Feed — Occurrence, Exposure, Margin of Exposure, and Risk Characterization (EFSA Journal 2017;15(7):4829) REGULATORY · 2017
• US FDA: Pyrrolizidine Alkaloids in Dietary Supplements — Comfrey, Butterbur, Coltsfoot, and Related Hepatotoxic Herbs; Guidance and Warning Letters (2001, updated 2015) REGULATORY · 2015
• where to look IARC Monographs — Monographs available (index) REGULATORY · 2026
• OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26) REGULATORY

The IARC classification shown under Regulatory Status is cited to the source below. It is a record-wide citation for that classification, not a source for the adult risk band.

• IARC Monographs Volume 10: Some Naturally Occurring Substances IARC

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